4D: a new round in bioprinting development

The first International Bioprinting Congress took place in Singapore. Vladimir Mironov, Chief Scientific Officer Laboratory for Biotechnological Research «3D Bioprinting Solutions», was one of the key speakers with his “4D bioprinting: biofabrication of tissue-engineered constructions using intelligent selfcomposing biomaterials” report. 
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Four-dimensional printing is another round in bioprinting development. “What it is? It is printing the material that is programmed for self-composing and self-assembling,” – explains the Head of research of the Russian lab. (Editorial note: a good example for illustration would be paper blocks from “do-it-yourself” kits, when all the block sides are given in a plane with the lines to fold. All the young constructor has to do it is glue them together in the right manner.)

“In 4D bioprinting the self-assembling happens according to the program with the change in temperature. – Vladimir Mironov continues. – Such technology can be used in both single- and bilayered printing, and we found one more solution for applying it. We take a selected matrix and plant spheroids on it; when the temperature changes, the matrix folds up. This technology is interesting enough and has high potential.”

The Congress featured the total of 14 reports by the leading scientists and research groups from all over the world, from Austria to Australia.

“This conference was unique as it gathered professionals only, - professor Mironov shared his impressions, - so during the discussion we could touch upon all the points of interest.”

During the two-day Congress, the colleagues shared the recent achievements in such fields as biological jet printing, manufacturing and production of cells and tissues for Lab-on-chip, biological laser printing, search of possibilities of merging the bio-additive manufacturing and microfabrication, biomaterials for tissue engineering, manufacturing and using of medical devices.

“Despite the fact that each scientist follows a distinct line of his own in developing the bioprinting technology, there is a clear overall foundation taking shape within this direction. – marked Vladimir Mironov. - The first is the development of the process automation using robotics. The second point is the fact that the leading scientific groups, like that of professor Koichi Nakayama from Saga University in Japan, ended up using spheroid printing. It confirms that the direction which we chosen, is the right one.” (Editorial note: a spheroid is a dropwise aggregation of living cells that serves as a kind of “printing unit” for the bioprinter. The authorship of this technology belongs to professor Vladimir Mironov.)

The attention was also drawn to the idea that Vladimir Mironov has long and repeatedly been suggesting about the next stage of bioprinting development: the creation of organ biofabrication line. Some scientific groups quickly picked up the idea and plan to work in that direction.
So what is actually this line? “The organ biofabrication line is a whole range of integrated robotic devices, - explains the Chief Scientific Officer of «3D Bioprinting Solutions», - which provide the smooth transition from the cell sorting process to the tissue spheroids production stage and then to the “printing” of the future implant structures. It is a kind of a mini-factory. A complete biofabrication production line (artificial manufacture of living organs) should include several automatic units: a patient cells’ sorter, a tissue spheroids biofabricator, a bioprinter and, finally, a bioreactor.”

“All these units are very sophisticated appliances, - professor Mironov continues, - and their development and perfecting are under way in full swing all over the world. For example, a modern cell sorter is capable of sorting out the needed stem cells composite from fat tissue in just 1 or 2 hours. In our Laboratory we are now designing our own bioreactor. And we will present our own bioprinter model at the “Open innovations” forum in October.”

Another event will take place as part of the “Open innovations 2014” forum. On October 15 (at Technopolis, Moscow) at 13:00, professor Vladimir Mironov will deliver a presentation dedicated to “Organ printing as the creative revolutionary technology”. Forum will be take place from 14 till 16 of October 2014 year. You can check out the detailed forum business program at: http://www.forinnovations.ru/forum/ 

The Biotechnology research laboratory is planning to present a 3D bioprinter of original construction and design presentation in the exhibition area on October 14-16.

Host site link: http://www.forinnovations.ru/for-pa
In addition, at the hosts’ site you can purchase the tickets to the exhibition and the business program.
Event description link: http://3dbioprinting.timepad.ru/event/128482/
Speaker link: http://www.forinnovations.ru/forum/speakers/vladimir-mironov/
Tickets can be purchased at the host site: http://www.forinnovations.ru/


About 3D Bioprinting Solutions:
Headquartered in Moscow, Russia, 3D Bioprinting Solutions is a biotech R&D company focusing on 3D bioprinting technology and working on the whole range of the hardware, materials, technologies, and products constituting this nascent industry. 3D Bioprinting Solutions was established in 2013 and since then has built a wide net of partners all over the world.


Inna Pantylina
PR Director
phone: +7 499 769 50 18
mob.: +7 962 971 51 40
e-mail: inna@bioprinting.ru