The aim of the symposium is to discuss the current state and prospects for the development of new biofabrication technologies and the possibility of their use in space.

A fundamentally new approach to bioprinting called "formative production”  is possible to enable in microgravity conditions. The bioprinters developed for carrying out such experiments will allow creating various organ constructs, including those sensitive to radiation, for assessing the adverse effect of cosmic radiation on the health of astronauts in the missions to the Moon and Mars.

The symposium will be attended by leading foreign and Russian experts in the field of experiments in space and biofabrication:

Dr. Demirci is currently a Professor at Stanford University School of Medicine with tenure at the Canary Center for Early Cancer Detection. Prior to his Stanford appointment, he was an Associate Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School and at Harvard-MIT Division of Health Sciences and Technology serving at the Division of Biomedical Engineering, Division of Infectious Diseases and Renal Division. He leads a group of 20+ researchers focusing on micro- and nano-scale technologies. He received his B.S. degree in Electrical Engineering in 1999 as a James B. Angell Scholar (summa cum laude) from University of Michigan, Ann Arbor. He received his M.S. degree in 2001 in Electrical Engineering, M.S. degree in Management Science and Engineering in 2005, and Ph.D. in Electrical Engineering in 2005, all from Stanford University. ology Review TR35 as one of the top 35 innovators in the world under the age of 35

Matteo Moretti is head of the Cell and Tissue Engineering Lab at IRCCS Galeazzi Orthopaedic Institute, Milan, Italy. Prior to this he worked as postdoctoral fellow at Massachusetts Institute of Technology, Harvard-MIT Div. of Health Science and Technology, Langer Lab. Both of his degrees, B.Eng (Politecnico di Milano) and research M.Sc (Trinity College Dublin, with Prof. P.J. Prendergast) are in Bioengineering. He obtained a European Ph.D from Politecnico di Milano, pursuing his research also in Prof. I. Martin’s Tissue Engineering Lab at U. Basel. 

His main research interests lie within osteochondral and cardiovascular tissues and bioreactor technologies. In particular, on engineered tissues and in vitro model systems, 3D tumor models, tissue vascularization and in multi-scale bioreactor systems as a key to more viable and accessible tissue and cell therapies. He is member of the TERMIS-EU Council and  invited Expert Reviewer for various Governments and Institutions, amongst which EU-FP7/HORIZON2020, UK BBSRC, Hong Kong ITC, Portugal FCT, German BMBF, Netherlands ZonMw and ETH Zurich. He has been awarded a number scientific prizes including a N.A.S.A. Tech Brief Award for development of scientific or technical innovations. Industrially, he has been coordinator of EU Projects for Fidia Advanced Biopolymers, has a licensed patent and is co-founder of 2 biotech startups (SKE s.r.l. and CELLEC A.G.) focused on bioreactor technologies.

Acting Deputy Director for Research, Institute of Biomedical Problems, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences. Lyudmila Buravkova is the author and co-author of more than 200 scientific articles, collective monographs on the mplementation of scientific programs on biosatellites, experimental studies involving human subjects in the modeling of space flight factors and factors of the hyperbaric habitat.

Currently Prof. Dr. Buravkova heads the department "Molecular Cell Biomedicine" and the laboratory "Cellular physiology". She is a recognized expert in the field of space biology, physiology of extreme states and gravitational cytophysiology.

Area of scientific interests:

• studying the cellular mechanisms of adaptation to hypoxia,

• Investigation of the role of intracellular signaling in adaptive reactions under the action of altered oxygen content and pressure of the gaseous medium,

• analysis of cellular effects under the action of space flight factors, the role of modification of the cytoskeleton and the expression of adhesion molecules when the cell adapts to altered gravity,

• Investigation of the plasticity of the progenitor cells and the intercellular interaction.

Prof. Dr. Buravkova is a full member of the International Academy of Astronautics (Paris), a member of the International Committee on High Pressure Biology, a member of the editorial board of the journals "Human Physiology", "Aerospace and Environmental Medicine" and "Cell Technologies in Biology and Medicine." In addition to scientific work, L. Buravkova is engaged in teaching activities, being a professor at the Department of Ecological and Extreme Medicine of the Faculty of Fundamental Medicine of the Lomonosov Moscow State University. Professor Buravkova heads the course of "Space Medicine" and lectures on barophysiology in the course of "Medical Ecology"

VLADIMIR MIRONOV

MD, PhD, Scientific Supervisor of the Biotechnology Research Laboratory 3D Bioprinting Solutions

Graduated in 1977 at the Faculty of Medicine, Ivanovo State Medical University (currently the Academy). The scientific degree of "candidate of medical sciences" in the specialty "Histology / Embryology" was received in 1980 in the 2 nd MOLGMI (in the present time RIIGU named after NI Pirogov).

1980-1985 - Assistant of the Department of Histology and Embryology, Ivanovo State Medical University (Academy).

1985-1990 - Senior Researcher of the Ivanovo Research Institute of Maternity and Childhood. 1990-1991 - Senior Researcher, Institute of Human Morphology, Russian Academy of Medical Sciences.

1991 - leaving for Germany, RWTH University of Aachen, to continue his studies, and then in 1992 - the Institute of Psychiatry of the Society. Max Planck.

1993 - Mironov VA was invited as a postdoctoral student at the Medical University of South Carolina (Medical University of South Carolina, USA).

2000 - Assistant Professor, since 2005 - Associate Professor Department of Regenerative Medicine and Cell Biology (in the Department of Regenerative Medicine and Cellular Biology), in parallel - Assistant Professor Department of Cell Biology and Anatomy (Department of Cell Biology and Anatomy). At the same time Mironov VA. headed by the Advanced Tissue Biofabrication Center, MUSC (Center for Advanced Bioprocessing at the Medical University of South Carolina, USA).

At present, VA Mironov is a professor at Virginia Commonwealth University, Department of Chemical and Life Science Engineering, conducts practical research at the Center for Information Technology, Renato Archer, Campinas, State of São Paulo (Information Technology Center Renato Archer (Campinas, Brazil)) and at the National Research University "MIET". Supervisor of the company 3D Bioprinting Solutions.

BIOFABRICATION IN SPACE: 

NEW OPPORTUNITIES FOR CONDUCTING BIOLOGICAL EXPERIMENTS

Proposed Preliminary Conference Program.

April 11, 2018. Skolkovo, Russia.

09:00 – 09:50          Registration. 

09:50 – 10:00          Greetings from the organizers of the conference. 

10:00 – 10:30          Lyudmila Buravkova (Institute of Biomedical Problems, Russia). 

10:30 – 11:00          Engin Ozcivici (Izmir Institute of Technology). Weightlessness and Bone Tissue. 

11:00 – 11:30          Markus Wehland (Otto-von-Guericke University Magdeburg, Germany). Tissue Engineering of Multicellular Spheroids under Microgravity Conditions. 

11:30 – 12:00          Sourabh Gosh (Indian Institute of Technology). Silk-based bioinks for 3D Bioprinting. 

12:00 – 12:30          Vladimir Mironov (3D Bioprinting Solutions, Russia). Formative biofabrication on Earth and in space. 

12:30 – 13:45          Lunch. 

13:45 – 14:30          Utkan Demirci (Stanford University, USA). Magnetically guided self-assembly and coding of 3d living architectures. 

14:30 – 15:00          Matteo Morretti (Regenerative Medicine Technologies Lab, Italy). Advanced 3D vascularized in vitro models of human musculoskeletal tissues.

15:00 – 15:10          The film dedicated to the 20th anniversary of the ISS. 

15:10 – 15:30          Direct connection with the ISS. 

15:30 – 16:00          Coffee-break. 

16:00 – 18:00          Round table with representatives of space agencies.