VIVAX BIO and 3D Bioprinting solutions obtained the data required to test formative production bioprinting technology in space experiment during ISS Expedition 57. The results demonstrate that the technology we have developed enables the fabrication of three-dimensional living tissue engineering and organ structures with the use of low concentrations of paramagnetic materials, significantly reducing the possible toxic effect of the latter on cell viability.

The ISS crew conducted all stages of the experiment in accordance with the onboard documentation. An analysis of photos and videos taken on the ISS showed the gradual fabrication of the constructs in natural microgravity.

Once we received samples back on Earth, we performed a histological evaluation of the three-dimensional constructs collected from the tissue spheroids.The histological analysis of tissue constructs shows that the cells inside the printed constructs are alive and have a typical morphology.

Data from the experiment confirmed the performance capabilities of the equipment and proved the feasibility of using three-dimensional magnetic bioprinting, which employs a magnetic field instead of a traditional solid biodegradable substrate "field". The magnetic bio-printer opens up new technological possibilities in the study of the physiology of tissue-engineered constructs, as well as enabling the printing of the complex structure of human organ constructs in natural microgravity in space. A further achievement was the development of a unified technology platform for various biotechnical studies based around the Russian segment of the ISS, including the possible use of crystals of inorganic and organic compounds in space microgravity fabrication, as well as bacterial biofilms.